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CJC-1295 Without DAC (MOD GRF 1-29) is a tetrasubstituted GHRH(1-29) analog with ~30-minute half-life — the preferred short-acting GHRH analog for pulsatile GH research protocols, commonly paired with ipamorelin.
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How it works
CJC-1295 Without DAC binds GHRH receptors with full agonism, stimulating pulsatile GH release via cAMP signaling in pituitary somatotropes. Four protective amino acid substitutions extend half-life from ~2 min (native GHRH) to ~30 min, enabling consistent somatotrope activation with physiologically patterned GH pulses. Synergistic with GHRPs (ipamorelin) via independent receptor systems.
Compound profile
Product definition
CJC-1295 Without DAC (MOD GRF 1-29) is a tetrasubstituted GHRH(1-29) analog with ~30-minute half-life — the preferred short-acting GHRH analog for pulsatile GH research protocols, commonly paired with ipamorelin.
CJC-1295 Without DAC (also called MOD GRF 1-29, Modified GRF(1-29), or tetrasubstituted GHRH(1-29)) is a synthetic GHRH analog engineered with four protective amino acid substitutions at positions 2 (Ala→Aib), 8 (Ala→Gln), 15 (Gly→Ala), and 27 (Met→Nle). These modifications address the principal enzymatic degradation pathways of native GHRH(1-29): - Position 2: Aib (α-aminoisobutyric acid) substitution prevents DPP-IV cleavage, the primary inactivation pathway - Position 8: Gln substitution protects against neutral endopeptidase cleavage - Position 15: Ala substitution reduces amide backbone hydrolysis susceptibility - Position 27: Nle substitution prevents methionine oxidation The combined effect of these substitutions extends the in vivo half-life from approximately 2 minutes (native GHRH) to approximately 30 minutes without altering GHRH receptor binding affinity or downstream GH secretion kinetics. The compound retains full receptor agonism while gaining pharmacokinetic stability — the fundamental engineering objective.
Research audience
CJC-1295 Without DAC is used by researchers studying GH pulse physiology, GHRH receptor pharmacology, GH secretagogue combination protocols, and pituitary somatotrope activation. It is the standard GHRH component in research protocols requiring pulsatile GH release without the sustained GH elevation profile of CJC-1295 With DAC.
Research context
The nomenclature history of this compound is worth understanding for research literature navigation. 'CJC-1295' was originally applied by ConjuChem Inc. to their tetrasubstituted GHRH(1-29) before the Drug Affinity Complex (DAC) modification was added. When the DAC modification was developed, the albumin-binding version became 'CJC-1295 With DAC' and the original version was retroactively called 'CJC-1295 Without DAC.' The underlying unmodified-by-DAC peptide is correctly designated MOD GRF 1-29 or GRF(1-29)NH2 in pharmacological literature — both names refer to the same molecule. In GH secretagogue research, CJC-1295 Without DAC is most commonly studied in combination with a GHRP (ipamorelin being the most common due to its selectivity profile). Multiple animal model studies have documented that the GHRH+GHRP combination produces significantly greater GH release than either compound alone — the synergy attributable to GHRH's priming of somatotrope pool responsiveness and GHRP's amplification of GH release magnitude via the distinct GHS-R1a pathway. For comparative protocol design, CJC-1295 Without DAC is the appropriate GHRH choice when the study requires pulsatile GH dynamics; CJC-1295 With DAC is the choice when sustained GH elevation over days is the protocol requirement.
Common questions
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MOD GRF 1-29
MOD GRF 1-29 (CJC-1295 Without DAC) is a tetrasubstituted GHRH(1-29) analog with ~30-minute half-life — the most commonly used short-acting GHRH compound for pulsatile GH secretion research.
GHRP-2
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Research Use Only
Sold for laboratory and research purposes only. Not approved for, nor intended for, human or veterinary consumption, diagnostic use, or therapeutic application. These products have not been evaluated by the Food and Drug Administration. Keep out of reach of children. For use by qualified researchers only.
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