BT5 - TB500 - 5 MG - Research Use Only

Name: BT5 - TB500 - 5 MG - Research Use Only
Brand: Peptific
SKU: BT5
Price: 18 USD
Availability: OutOfStock

Thymosin Beta 4 (TB-500) is a 43-amino-acid actin-sequestering peptide studied in preclinical models for cardiac repair, wound healing, tissue regeneration, and anti-inflammatory activity.

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$18.00

Thymosin Beta 4 (TB-500)-

$18.00

✓HPLC purity tested
✓COA per lot, on request
✓Lyophilized, sealed
✓US shipping, tracked

Studied in preclinical cardiac models for cardiomyocyte survival and infarct size reduction
Investigated for wound closure acceleration and dermal regeneration in animal studies
Examined for hair follicle activation and hair regrowth stimulation in rodent models
Researched for tendon and ligament tissue repair in orthopedic preclinical protocols
Explored for anti-inflammatory mechanisms including macrophage polarization in injury models

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Research Supplies

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In your order

What ships when you order Thymosin Beta 4 (TB-500)

Lyophilized vial
Sterile-filtered, freeze-dried peptide in glass vial, sealed under inert gas.
Lot ID on every vial
Printed lot ID ties this exact vial to its analytical record.
COA on request
Independent third-party HPLC certificate, matched to your lot, sent on request.
Carrier-tracked shipping
Shipped from a US facility with full carrier tracking and protective packaging.

The Peptific standard

Why researchers buy from Peptific instead of grey-market vendors

Peptide quality is invisible until it isn’t. Lot identity, purity, fill integrity, and chain of custody are the difference between usable research material and wasted budget.

Third-party HPLC tested
Every lot is tested for identity and purity by an independent analytical lab. Certificate of Analysis available on request, tied to the exact lot you receive.
Lyophilized and lot-tracked
Sterile-filtered, freeze-dried, sealed under inert gas. Each vial carries its own lot ID — full chain of custody from fill to delivery.
US-based fulfillment
Orders ship from a temperature-controlled US facility with carrier tracking. No drop-shipping, no opaque overseas relay.
Real support, not a ticket queue
A real person responds to research questions, lot questions, and order questions — usually same business day. No bot triage.

How it works

The Thymosin Beta 4 (TB-500) mechanism

TB-500 binds G-actin through its LKKTET motif, regulating actin polymerization and promoting cell migration — a key process in tissue repair. Preclinical research has associated this mechanism with accelerated wound closure, cardiac muscle recovery, and reduced fibrosis in animal injury models. Its systemic distribution of activity across multiple tissue types is a defining feature of its research profile.

Compound profile

Class: Actin-sequestering peptide
Amino acids: 43
Molecular weight: ~4,961 Da
Origin: Thymic protein; now synthetic
Key motif: LKKTET (actin-binding domain)
CAS: 77591-33-4
Research category: Cardiac repair, wound healing, tissue regeneration
Storage: Lyophilized: −20°C. Reconstituted: 2–8°C, use within 30 days

Product definition

What is Thymosin Beta 4 (TB-500)?

Thymosin Beta 4 (TB-500) is a 43-amino-acid actin-sequestering peptide studied in preclinical models for cardiac repair, wound healing, tissue regeneration, and anti-inflammatory activity.

Thymosin Beta 4 is a naturally occurring 43-amino-acid peptide originally isolated from thymic tissue. As the most abundant actin-sequestering protein in most mammalian cells, it plays a central role in cytoskeletal dynamics by maintaining the pool of unpolymerized G-actin available for rapid mobilization during cell movement and repair. In preclinical research, TB-500 has been studied in models of myocardial infarction (where it is associated with cardiomyocyte survival and reduced infarct size), wound healing (accelerated epidermal and dermal closure), hair follicle activation, and tendon/ligament injury. Its anti-inflammatory properties have been investigated in multiple models, with researchers noting effects on macrophage polarization and cytokine expression in injured tissue.

Research audience

Who studies Thymosin Beta 4 (TB-500)?

TB-500 is researched by scientists in cardiovascular biology, wound healing, orthopedic repair, dermatology preclinical work, and inflammation research. Its broad activity profile makes it a cross-disciplinary compound with relevance across multiple research categories.

Research context

What does the preclinical literature say about Thymosin Beta 4 (TB-500)?

Thymosin Beta 4 was first characterized as the principal actin-sequestering protein in the thymus and has been studied as a potential repair peptide since the 1990s. The research group of Hanna Kleinman at the NIH was pivotal in establishing its wound-healing properties, and subsequent work has expanded the research base significantly across cardiac, neural, and musculoskeletal models. In cardiac research, TB-500 administration in rodent myocardial infarction models has been associated with preserved ejection fraction, reduced scar formation, and promotion of angiogenesis in the infarct border zone. This line of investigation has produced multiple peer-reviewed publications and positioned TB-500 as a candidate for further study in cardiac regeneration research. In wound-healing and dermal research, TB-500 has been studied for its effects on keratinocyte and endothelial cell migration — both critical for wound closure. The compound's ability to promote blood vessel formation (angiogenesis) in wound beds has been documented in multiple rodent cutaneous wound models.

Common questions

Why is TB-500 often combined with BPC-157?

BPC-157 and TB-500 target different proposed mechanisms — BPC-157 through NO-system and angiogenesis in localized tissue models, TB-500 through actin regulation and systemic cell-migration promotion. Researchers studying tissue repair often combine them because the mechanisms appear complementary. The Wolverine Blend on this site combines both in a single research formulation.

What is the difference between TB-500 and Thymosin Beta 4?

TB-500 is the research peptide label for synthetic Thymosin Beta 4. The compounds are structurally identical — both are the same 43-amino-acid sequence. The TB-500 naming convention is used in research supply contexts to distinguish the synthetic analog from endogenous Thymosin Beta 4 in biological samples.

Is the cardiac research on TB-500 replicated across multiple labs?

Yes. The cardiac repair research profile on TB-500 includes work from multiple independent research groups beyond the original NIH studies, including groups focused on heart failure, ischemia-reperfusion injury, and stem cell activation. The breadth of independent replication is part of what makes TB-500 one of the more data-rich peptides in the cardiac repair research literature.